Canonical Transient Receptor Potential Channel 3 Contributes to Cerebral Blood Flow Changes Associated with Cortical Spreading Depression in Mice

Cortical spreading depression is a pathophysiological event shared in migraines, strokes, traumatic brain injuries, and epilepsy. It associated with complex hemodynamic responses, which, turn, contribute to neurological problems. In this study, we investigated the role of canonical transient receptor potential channel 3 (TRPC3) responses elicited by cortical depression. Cerebral blood flow was monitored using laser speckle contrast imaging, triggered three well-established experimental approaches mice. A comparison TRPC3 knockout mice controls revealed that genetic ablation expression significantly altered promoted hyperemia consistently. Our results indicate contributes could be novel therapeutic target for host disorders.